Job Title: Senior Research Associate – Bioconjugation / ADC Development (Contractor)

Work Location: Grafton County, NH

Summary:

This is a 6-to-9 month on-site contractor position for a Senior Research Associate specializing in bioconjugation and in vitro assays. The role focuses on the development, purification, and characterization of antibody-targeted therapeutics for chronic inflammatory and autoimmune diseases. The position offers the opportunity to contribute to innovative biologics and conjugated therapeutics in a fast-paced, collaborative environment.

Responsibilities:

• Lead bioconjugation, purification, and characterization of biologics, including antibodies and oligonucleotides, using advanced chromatographic techniques.
• Optimize and troubleshoot conjugate purification processes at gram scale, utilizing affinity, ion-exchange, hydrophobic interaction, and size exclusion chromatography, as well as tangential flow filtration.
• Perform buffer exchange and concentration processes to support downstream applications.
• Conduct comprehensive analytical characterization of antibody drug conjugates using methods such as UV-Vis, SEC, HIC, RP-HPLC, and IEX.
• Support formulation development and stability studies for antibody and oligonucleotide conjugates.
• Execute in vitro assays, including ELISA, RNA isolation, and cell-based assays, to evaluate candidate molecules.
• Collaborate with internal teams and external partners to advance research project goals and ensure effective cross-functional communication.
• Maintain accurate scientific documentation and ensure data integrity throughout all research activities.

Qualifications:

• MS degree in biochemistry, chemistry, or related field with at least 4 years of relevant experience.
• Hands-on experience in bioconjugation, conjugate purification, and characterization, including use of AKTA Pure FPLC systems and Agilent 1260 HPLC.
• Proficiency in buffer exchange and concentration techniques.
• Demonstrated ability to execute in vitro assays such as ELISA, RNA isolation, and cell-based assays.
• Experience with ADC/AOC formulation and stability studies is preferred.
• Strong problem-solving skills, scientific curiosity, and ability to work independently in a fast-paced environment.
• Excellent communication, attention to detail, and interpersonal skills, with a collaborative and goal-oriented working style.
• Proven track record of working effectively in dynamic, cross-functional teams and maintaining outstanding organizational abilities.

Published Category: Discovery Research & Preclinical