Chemistry Contractor

Work Location: Middlesex County, Massachusetts

Summary:

Seeking a motivated chemist to join an interdisciplinary drug discovery team. This lab-based role involves supporting medicinal chemistry efforts and contributing to both automated peptide synthesis and small molecule synthesis, depending on project needs. Ideal candidates are passionate, energetic, and experienced in synthetic organic chemistry, eager to thrive in a fast-paced discovery environment.

Responsibilities:

• Drive synthesis of peptide libraries to enhance binding affinity, permeability, and drug-like properties.
• Utilize automated peptide synthesizers and perform both solid-supported and solution-phase reactions as needed.
• Identify and resolve synthetic challenges, proposing practical solutions to advance research programs.
• Maintain detailed experimental records and communicate findings clearly to project teams.
• Collaborate with team members to address evolving chemistry requirements across multiple projects.
• Adapt to shifting priorities between small molecule and peptide synthesis based on project demands.
• Apply analytical techniques, including LC-MS, to characterize and purify synthesized compounds.
• Contribute to a collaborative, fast-paced laboratory environment, ensuring project milestones are met.

Qualifications:

• BS in Chemistry or related field with 1-3+ years of industry or academic research experience in synthetic organic chemistry.
• Strong foundation in organic chemistry, reaction mechanisms, and modern synthetic methods.
• Hands-on laboratory experience, including reaction setup, purification, and compound characterization.
• Proficiency with LC-MS and standard analytical techniques.
• Experience with peptide synthesis (SPPS or automated platforms) preferred but not required.
• Flexibility to transition between small molecule and peptide synthesis as project needs change.
• Excellent problem-solving skills, attention to detail, and ability to meet deadlines.
• Strong written and oral communication skills; effective in a collaborative team environment.
• Ability to work on-site and attend in-person meetings.

Published Category: Discovery Research & Preclinical