Details:

  • Compensation: $100,000 - $130,000k
  • Benefits: Medical, Dental, Vision
  • Employment Classification: Direct Hire
  • Status: On-Site
  • Job ID: 21480
Scientist – Screening & Analytical Chemistry

Job Title: Scientist – Analytical Chemistry

Work Location: Middlesex County, Massachusetts

Summary:

Seeking a Scientist in Screening & Analytical Chemistry to drive the development and optimization of high-throughput analytical workflows, focusing on rapid, targeted metabolite quantification and integration with screening pipelines. This hands-on role requires collaboration within multidisciplinary teams and a high degree of flexibility, creativity, and initiative.

Responsibilities:

  • Design and implement high-throughput analytical workflows for rapid metabolite quantification.
  • Develop and optimize methods on GC/MS, GC-FID, and LC-QQQ-MS platforms for targeted analysis.
  • Create and refine sample preparation and derivatization strategies for complex matrices.
  • Collaborate with automation and screening teams to support microtiter plate-based fermentations.
  • Analyze, interpret, and manage large datasets generated from screening activities.
  • Mentor and provide technical guidance to junior staff members.
  • Maintain and troubleshoot analytical instrumentation, interfacing with vendors as needed.
  • Author standard operating procedures (SOPs) and technical reports to document workflows and findings.

Qualifications:

  • PhD in Analytical Chemistry, Chemistry, or related field; or MS with 8+ years, or BS with 13+ years of relevant experience.
  • Extensive experience in analytical method development and optimization.
  • Expertise in GC-FID and GC/MS assay development for targeted quantitation and metabolite profiling.
  • Proficiency in LC/QQQ-MS assay development for targeted quantitation.
  • Demonstrated ability to optimize assays for speed, sensitivity, and throughput.
  • Experience in high-throughput screening environments and integration of analytical workflows with automation.
  • Familiarity with liquid handling platforms and laboratory information management systems (LIMS).
  • Hands-on experience with UHPLC, GC-FID, GC/MS, and LC/QQQ-MS instrumentation.
  • Knowledge of sample extraction and preparation techniques from complex matrices, including microbial fermentation broth, biomass, and purified extracts, with automated solutions when appropriate.
  • Industrial biotechnology or applied R&D experience is a plus.

Published Category: Analytical & Process Development

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