Senior Scientist / Principal Scientist

Responsibilities:

• Lead and support formulation development activities for oligonucleotide drug products, focusing on process optimization and troubleshooting to enhance product quality.
• Prepare and assess formulations for preclinical in vivo and non-human primate studies.
• Conduct and interpret analytical characterization of drug substances and products to inform development decisions.
• Coordinate technical activities and maintain effective communication with internal teams and external partners across process development, analytical development, manufacturing, and scale-up.
• Contribute to CMC documentation and regulatory submissions in support of IND-enabling activities.
• Drive program execution through cross-functional planning, organization, and collaboration.
• Act as a key liaison between internal scientific teams and external collaborators to move pipeline programs forward.
• Bring strong scientific judgment and creative problem-solving to a fast-moving, team-oriented environment.

Qualifications:

• PhD in Chemistry, Pharmaceutical Sciences, Chemical Engineering, or a related field; MS candidates with significant relevant industry experience will be considered.
• 5+ years of industry experience in CMC development within pharma or biotech.
• Hands-on background in oligonucleotide and/or conjugate formulation development.
• Solid understanding of phase-appropriate CMC strategy and regulatory documentation requirements.
• Prior experience working with CDMOs or other external development and manufacturing partners is a plus.
• Strong attention to detail, sound scientific judgment, and a collaborative mindset.
• Comfortable operating in a dynamic, high-growth environment.