Job Title: Synthetic Chemist 

Work Location: Middlesex County, MA

Summary:

This position bridges practical laboratory synthesis with digital innovation, focusing on synthetic strategy, workflow development, and integration of AI tools to accelerate and optimize drug discovery processes. The role involves leadership in synthetic chemistry, collaboration with cross-functional teams, and mentorship of junior staff.

Responsibilities:

• Design, optimize, and troubleshoot synthetic routes for a variety of chemotypes and medicinal chemistry programs.
• Develop and implement supply strategies for compounds and intermediates, including route optimization and scale-up activities.
• Oversee and coordinate synthesis activities with multiple contract research organizations (CROs), managing both FTE-based and fee-for-service projects.
• Utilize technology platforms and chemistry expertise to ensure timely delivery of high-quality compounds.
• Translate laboratory knowledge into digital workflows for route design, reaction condition selection, CRO communication, and compound tracking.
• Contribute to the development and refinement of AI tools that support synthesis decision-making and workflow efficiency.
• Train and mentor laboratory technicians to ensure safe, effective, and reproducible execution of reactions.
• Collaborate with cross-functional teams to communicate synthetic strategies and resolve technical challenges.

Qualifications:

• Ph.D. in Organic or Synthetic Chemistry with 5+ years of hands-on synthesis experience, or B.S./M.S. with 7–10+ years of relevant experience.
• Extensive knowledge of modern synthetic methods and practical laboratory skills.
• Demonstrated ability to solve complex synthetic problems across diverse chemotypes, reaction types, and scales.
• Experience managing synthesis projects with CROs, including both FTE-based and fee-for-service models.
• Proven experience mentoring junior chemists or laboratory technicians.
• Strategic judgment in material supply, route optimization, and scale-up decisions.
• Strong communication skills and ability to work collaboratively across disciplines.
• Experience with scale-up synthesis for in vivo toxicology studies or late-stage discovery work is preferred.
• Background in process chemistry is advantageous.
• Familiarity with AI, automation, or digital tools in synthesis workflows is a plus.
• Experience spanning medicinal chemistry, computational chemistry, and experimental drug discovery is desirable.

Published Category: Discovery Research & Preclinical