Job Title: Associate / Sr. Associate Scientist Antibody and Protein Engineering

Work Location: Suffolk County, Massachusetts

Summary:

Join a dynamic protein engineering team to contribute to the discovery and engineering of biotherapeutic leads. This role involves hands-on laboratory work in antibody and protein expression, purification, and characterization, with opportunities to collaborate across scientific disciplines and present findings to diverse audiences.

Responsibilities:

• Design and conduct laboratory experiments to support antibody and protein engineering initiatives, following guidance from project leads.
• Perform expression and purification of monoclonal and bispecific antibodies, optimizing and troubleshooting workflows as needed.
• Characterize antibody and protein molecules using biochemical and biophysical techniques such as BLI, ELISA, HPLC/FPLC, and SDS-PAGE.
• Assess quality, purity, and stability of antibodies/proteins to identify technical or developability issues.
• Independently analyze and interpret experimental data, drawing conclusions and recommending next steps.
• Maintain mammalian cell cultures (HEK293 and CHO), ensuring proper cell line management and documentation.
• Document experimental procedures, results, and conclusions accurately in electronic laboratory notebooks.
• Troubleshoot experimental challenges, implement solutions, and contribute to continuous improvement of laboratory methods and workflows.

Qualifications:

• B.S. or M.S. in Biochemistry, Molecular Biology, Protein Sciences, or related field, with relevant industry experience.
• Minimum 2 years of industry R&D experience for Associate Scientist (with B.S.); minimum 5 years (with B.S.) or 3 years (with M.S.) for Senior Associate Scientist.
• Hands-on experience with mammalian cell culture, recombinant protein expression, and protein purification.
• Experience with bispecific antibodies or engineered antibody formats is highly desirable.
• Proficiency in biochemical and biophysical characterization techniques, especially BLI, ELISA, HPLC/FPLC, and SDS-PAGE.
• Ability to independently execute experiments, troubleshoot technical issues, and manage multiple priorities.
• Strong skills in data analysis, interpretation, and scientific communication to both project teams and broader audiences.
• Attention to detail and commitment to high-quality documentation and data integrity.
• Experience in high throughput screening assays using FACS is a plus.
• Experience with AKTA-FPLC instruments for protein purification is preferred.
• Proficiency in mammalian cell culture, including media preparation, cell line maintenance, cryopreservation, and transfections.
• Ability to work collaboratively in a fast-paced, cross-functional research environment.

Published Category: Discovery Research & Preclinical